Do you have constipation associated with narcotic use? Opioids such as morphine, codeine, Oxicodone, Vicodin, Dilaudid, Percodan are used for the treatment of chronic pain. These medications may result in constipation. Current treatment of this type of constipation is extremely difficult and frequently unsuccessful.  There has been a need for a medication that blocks the effect of the narcotics on the gastrointestinal tract. New medications, currently being studied are showing great promise in relieving this constipation side-effect without reducing the pain control.